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QCM-D Quartz Crystal Microbalance with Dissipation Monitoring

Q-Sense instruments - tracking changes at the surface - are based on the patented QCM-D technique. The instruments measure in real-time the mass of molecular layers that form on the quartz sensor. Simultaneously structural (viscoelastic) properties of such molecular layers are monitored, which enables distinction between two similar interactions or observation of a phase transition in bound layers. Measurements of both mass and structural properties gives a thorough understanding of binding events such as molecular adsorption and interaction. Moreover, the QCM-D technique makes it possible to extract water content of molecular layers, in contrast to optical mass measurements, and allows several kinds of substrates such as metals, polymers and functionalised coatings for controlled studies of interactions. This enables the extraction of various informations about e.g. Kinetics, Affinity, Specifity, Structure, Mass, Film thickness

Q-Sense offers complete turnkey systems that include everything that is needed to quickly get started and produce high quality data. The instrument will be installed in your laboratory and the users will be educated in order to gain the full potential of QCM-D.

Detailed Information

Einführung in die QCM-D Technik (PDF, 217 KB)

Q-Sense E4: Rapid characterisation of biointerfaces

Q-Sense E1 - accurate individual sample analysis in one flow module

Sensor Crystals

Immobilization protocols

Brochures

Quartz Crystal Microbalance with Dissipation (QCM-D) (PDF, 326 KB)

QCM-D Sense the difference (PDF, 537 KB)

QCM-D Applications Biosurfaces in depth (PDF, 644 KB)

Tracking Changes at the surface: Q-Sense E4 (PDF, 609 KB)

QCM-D modules for different applications (PDF, 341 KB)

Application examples

Humidity uptake of starch

Analysing vapor uptake & release with QCM-D (PDF, 177 KB)

QCM-D and Ellipsometry

Combined QCM D Ellipsometry setup for real time (PDF, 917 KB)

Cleaning effect of detergents

Analyzing, cleaning and degradation Processes (PDF, 196 KB)

bio materials

Hemocompatibility of Hydroxyapatite (PDF, 320 KB)

protein interaction

Functionalised lipid bilayer for specific protein interaction studies (PDF, 142 KB)

protein adsorption

Protein adsorption as biocompatibility evaluation method for implant surfaces (PDF, 127 KB)

protein conformation

Structural change of adsorbed protein layer (PDF, 252 KB)

DNA hybridisation

Specificity of DNA hybridisation on a functionalised lipid bilayer (PDF, 296 KB)

Enzymatic activity on antibodies

Analyzing enzymatic activity on functionalized surfaces (PDF, 243 KB)

enzyme/detergent activity

Enzymatic degradation of lipid films caused by lipase (PDF, 599 KB)

lipid membrane formation

Lipid bilayer formation; a comparison between QCM-D SPR and AFM (PDF, 138 KB)

CaP growth / Biomineralization

Nucleation of calcium phosphate crystals on polyelectrolyte multilayers (PDF, 209 KB)

polyelectrolyte multilayer build-up

Real time thickness monitoring of polyelectrolyte multilayer formation in situ (PDF, 182 KB)

bacteria adhesion / biofilm formation

Early detection of biofilm formation on steel surfaces (PDF, 231 KB)

polymer/cellulose swelling

Swelling kinetics of a cellulose model film (PDF, 163 KB)

low-Mw molecule / surfactant adsorption

Low molecular weight surfactant adsorption to a gold surface (PDF, 180 KB)

protein fibrillation

Protein fibrillation studied with QCM-D (PDF, 226 KB)

molecular conformational effects

QCM-D study of molecular conformational effects on protein - DNA interactions (PDF, 326 KB)

viscosity measurements

Viscosity measurements with QCM-D (PDF, 175 KB)

QCM-D and microscopy of cells

Simultanous QCM-D and microscopy monitoring of cell Adhesion with the q-sense window module (PDF, 297 KB)

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Your contact:

Dr. Jürgen Schlütter
Phone: +49 6151 880644
Fax: +49 6151 880689
schluetter@lot-oriel.de

Dr. Raimund Sauter
Phone: +49 6151 880624
Fax: +49 6151 8806924
sauter@lot-oriel.de

Links:


Quantum Design:
→	www.qd-international.com

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	LOT-Oriel GmbH & Co. KG E-mail: q-sense@lot-oriel.de				Im Tiefen See 58 D-64293 Darmstadt				Phone: +49 6151 - 88 06 0 Fax: +49 6151 - 896667		emotiv design